Harmine Lengthens Circadian Period of the Mammalian Molecular Clock in the Suprachiasmatic Nucleus
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چکیده
منابع مشابه
Harmine lengthens circadian period of the mammalian molecular clock in the suprachiasmatic nucleus.
The circadian clock is a cell-autonomous endogenous system that generates circadian rhythms in the behavior and physiology of most organisms. We previously reported that the harmala alkaloid, harmine, lengthens the circadian period of Bmal1 transcription in NIH 3T3 fibroblasts. Clock protein dynamics were examined using real-time reporter assays of PER2::LUC to determine the effects of harmine ...
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The integration of time from gene to system levels is an exciting feature of circadian biology. In mammals, clock cells in the suprachiasmatic nucleus (SCN) generate time by an autoregulatory transcription-(post)translational feedback loop. Clock activity in the SCN neurons is expressed as activity-dependent electric signals, which are coupled to those of other SCN neurons. The SCN spreads the ...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2014
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00229